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Moreover, oxidation of AAT may lead to a loss of its anti-protease activity that is already lower in AATD, so the antioxidant potential in the treatment of emphysema patients with AATD needs to be considered
introducing high doses of glutathione too rapidly can occasionally trigger a "Herxheimer" or detoxification reaction, where the sudden mobilization of stored toxins temporarily exacerbates symptoms like fatigue, brain fog, or mild nausea
doi: 10.1038/nature19084 25 NwosuZCWardMHSajjakulnukitPPoudelPRagulanCKasperekSet al
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The Future of Glutathione Research Scientific interest in how Glutathione works is growing, with studies exploring its role in everything from neurodegenerative diseases to metabolic disorders
Furthermore, GSTP1-1 has also been shown to bind and inhibit tumor necrosis factor receptor-associated factor 2 (TRAF2), an upstream activator of JNK, thus blocking the MAPK/JNK signaling cascade at multiple levels 29
